Urban sound planning in Brighton and Hove

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Rates of genome evolution and branching order from whole genome analysis

Accurate estimation of any phylogeny is important as a framework for evolutionary analysis of form and function at all levels of organization from sequence to whole organism. Using alignments of nonrepetitive components of opossum, human, mouse, rat, an

Sounding Brighton: practical approaches towards better soundscapes

“Sounding Brighton” is a collaborative project exploring practical approaches towards better soundscapes focusing on soundscape issues related to health, quality of life and restorative functions of the environment. The project provides the opportunity to raise awareness and promote communication on soundscapes among the general public, stakeholders and those involved in policy, including encouraging exploration of new ways of listening in local soundscapes, and new ways of tackling noise and improving local soundscape quality. The project is working to provide opportunities to discuss how soundscape concepts might, alongside tackling conventional noise problems, contribute to local planning and environmental improvement as part of a citywide engagement process in the city of Brighton & Hove in England in the United Kingdom. A range of environments: e.g. city centre, entertainment venues, seafront, foreshore, historic terraces, squares, lanes, parks and gardens are being considered. A soundmap of the city is being developed; a public outreach exhibition has taken place; and a night noise intervention pilot study has been trialed to explore the relationship between soundscapes and the brain and their effects on human behavior. The work is being further developed to better understand the effect of soundscapes on community well being, social cohesion and the physical and mental health of individuals

Parallel adaptive radiations in two major clades of placental mammals

International audienc

Equitable expanded carrier screening needs Indigenous clinical and population genomic data

Expanded carrier screening (ECS) for recessive monogenic diseases requires prior knowledge of genomic variation, including DNA variants that cause disease. The composition of pathogenic variants differs greatly among human populations, but historically, research about monogenic diseases has focused mainly on people with European ancestry. By comparison, less is known about pathogenic DNA variants in people from other parts of the world. Consequently, inclusion of currently underrepresented Indigenous and other minority population groups in genomic research is essential to enable equitable outcomes in ECS and other areas of genomic medicine. Here, we discuss this issue in relation to the implementation of ECS in Australia, which is currently being evaluated as part of the national Government’s Genomics Health Futures Mission. We argue that significant effort is required to build an evidence base and genomic reference data so that ECS can bring significant clinical benefit for many Aboriginal and/or Torres Strait Islander Australians. These efforts are essential steps to achieving the Australian Government’s objectives and its commitment “to leveraging the benefits of genomics in the health system for all Australians.” They require culturally safe, community-led research and community involvement embedded within national health and medical genomics programs to ensure that new knowledge is integrated into medicine and health services in ways that address the specific and articulated cultural and health needs of Indigenous people. Until this occurs, people who do not have European ancestry are at risk of being, in relative terms, further disadvantaged